You'll have to assess the risk of contracting malaria against the potential impact of the drugs and that's best done in the company of a medical practitioner well versed in tropical medicine. A number of these drugs can cause anywhere from mild to severe side effects. Chloroquine can cause nausea, the antibiotic doxycycline makes it easier for you to get sunburned, and mefloquine can provoke severe psychological disturbances. I've taken mefloquine (Larium) without suffering any side effects but Tim, a fellow backpacker in Zimbabwe, began experiencing severe nightmares from mefloquine and had to go off the drug. There seems to be agreement that the drug with the least side effects is the newest one, Malarone. I've taken it for trips to both Panama and Senegal and haven't felt any side effects at all. What pills you take will depend on where you're going. Malaria in certain areas has developed a resistance to common drugs like chloroquine, and even to the newer mefloquine so you'll have to make sure you take the drug that is appropriate to your destination. Most of Central America and the Middle East, for example, tends to be suitable for chloroquine, but huge swathes of South America, Africa, South and Southeast Asia are resistant to it. So make sure you tell your doctor exactly where you're going (and for how long, because that also affects which drug you'll take). Come armed with some research if your doctor isn't a tropical medicine specialist. Be aware that not all parts of a country are necessarily a malaria risk. Here again, experts disagree. Some say take the pills no matter where you go in the country, while others say do so only if you're going to malarial areas. It's likely you'll face fewer risks in the cities. For example, you won't have to worry about malaria in Bangkok, but you will have to in the rural north and south. And Rio doesn't carry the same risks as the Amazon. Altitude also plays a part: malaria tends to occur at lower altitudes and anything above 1500m should be less worrisome. If avoiding malaria hasn't workedEven if you're careful you may still get malaria so best to know the symptoms: similar to flu, including fever, chills headache, aching muscles, tiredness, nausea and diarreha. It usually starts with the shivers, after which you get hotter and hotter until you sweat profusely. If you develop these symptoms when you're in a malaria risk area, it is essential to get to a doctor. Otherwise you may be at risk of developing cerebral malaria, which can be fatal. A simple blood test, available throughout the developing world, will determine whether you're infected, and treatment is widely available. Avoiding malaria is one thing, but there's also dengue fever, a painful disease that can take a long time to subside and makes your bones feel like they're breaking (this from a friend who caught it in Thailand). Like malaria there is no vaccine, and also like malaria, dengue requires avoiding bites by covering up and using repellent. It is found in similar climates, tropical and sub-tropical, with the difference that mosquitoes bite during the day. The bad news: where malaria and dengue coexist, you'll have to take major precautions both day and night.
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