The Western Hemisphere can be divided into any number of sections - North America, South and Central America, the Caribbean, Latin America... so for expediency I've split it into North America - the USA, Canada and non-Spanish speaking countries and colonies - and Latin America, where Spanish or Brazilian Portuguese are spoken.
As someone who is both Canadian and French, traveling through North America feels familiar, my only regret being that I haven't seen more of the continent.
Latin America feels a bit less familiar but not altogether foreign. I was brought up in Spain as a child and speak Spanish fluently, which makes travel here a lot easier. If you're a non-Latin woman traveling solo, Latin America probably wouldn't be your first choice. There's the language, of course, but also a dose of machismo which may be foreign to you.
Should you choose to take the plunge, you'll be royally rewarded with cultural immersion at its best: ancient civilizations, exciting foods, modern cities and music and art that can be unbeatable. There are many countries I haven't visited on the continent, but I do plan to.